|InterJournal Complex Systems, 1296
|Manuscript Number: |
Submission Date: 2004
|Sensitivity Analysis of Optimal Production of Biomass in Metabolic Networks|
Metabolic analysis at system level is essential for understanding biological system. Mathematic models and computational algorithms are a key to the success of metabolic analysis at system level. Flux-balance analysis (FBA) is a powerful tool for developing mathematic model of genome-wide metabolic analysis. Operating principle of metabolic networks is to seek optimal distribution of metabolic flux under constraints of available molecular resources, which determines metabolic phenotypes. In this report, we will use linear programming and nonsmooth optimization to study how metabolic networks respond environmental perturbation and assess network stability.
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