|InterJournal Complex Systems, 215
|Manuscript Number: |
Submission Date: 981117
|Evolution of Efficient strategies for evolution: Chance Favors the Prepared Genome|
Subject(s): CX.16, CX.35, BG.10, BG.2, BG.1
Category: Review Article
Efficient strategies for genome evolution emerge under the pressure of natural selection. These strategies provide a route through the space of possible genomes, and thus a selective advantage, as evolutionary innovation need not await the results of purely random mutation. Natural selection acts not only on individual gene products, but, at a higher level, on the mechanisms that generate diversity, and the sequence specificity of their actions. DNA sequences encode information that modulates the rate of genetic alteration; thus, genetic variation can become less probable at sites at which variation disturbs the active scaffold or other essential residues. The fittest strategies survive, along with the genomes that encode them.
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